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Mitigating skin color bias in dermatology AI using CycleGAN-based data augmentation

Kannan et al. | Jun 24, 2026

Mitigating skin color bias in dermatology AI using CycleGAN-based data augmentation
Image credit: Kannan and Ramasamy

This study investigates skin tone bias in artificial intelligence models used for dermatological disease classification and evaluates a CycleGAN-based data augmentation approach to improve diagnostic performance on darker skin types. We generated synthetic dark-skinned images to enhance dataset diversity and compared model performance before and after augmentation. The results demonstrate that augmentation with synthetic dermatological images can help reduce disparities in diagnostic performance across skin tones, highlighting a practical strategy for improving fairness in dermatology AI systems.

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Quantitative definition of chemical synthetic pathway complexity of organic compounds

Baranwal et al. | Jun 19, 2023

Quantitative definition of chemical synthetic pathway complexity of organic compounds

Irrespective of the final application of a molecule, synthetic accessibility is the rate-determining step in discovering and developing novel entities. However, synthetic complexity is challenging to quantify as a single metric, since it is a composite of several measurable metrics, some of which include cost, safety, and availability. Moreover, defining a single synthetic accessibility metric for both natural products and non-natural products poses yet another challenge given the structural distinctions between these two classes of compounds. Here, we propose a model for synthetic accessibility of all chemical compounds, inspired by the Central Limit Theorem, and devise a novel synthetic accessibility metric assessing the overall feasibility of making chemical compounds that has been fitted to a Gaussian distribution.

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