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siRNA-dependent KCNMB2 silencing inhibits lung cancer cell proliferation and promotes cell death

Jeong et al. | Nov 01, 2022

siRNA-dependent KCNMB2 silencing inhibits lung cancer cell proliferation and promotes cell death

Here, seeking to better understand the genetic associations underlying non-small cell lung cancer, the authors screened hundreds of genes, identifying that KCNMB2 upregulation was significantly correlated with poor prognoses in lung cancer patients. Based on this, they used small interfering RNA to decrease the expression of KCNMB2 in A549 lung cancer cells, finding decreased cell proliferation and increased lung cancer cell death. They suggest this could lead to a new potential target for lung cancer therapies.

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Determining the Effects of Fibroblast Growth Factor 2 on the Regenerative Abilities of Echinometra lucunter Sea Urchins

Kisling et al. | Feb 12, 2019

Determining the Effects of Fibroblast Growth Factor 2 on the Regenerative Abilities of Echinometra lucunter Sea Urchins

As humans, not all our body organs can adequately regenerate after injury, an ability that declines with age. In some species, however, regeneration is a hallmark response that can occur limitless numbers of time throughout the life of an organism. Understanding how such species can regenerate so efficiently is of central importance to regenerative medicine. Sea urchins, unlike humans, can regenerate their spinal tissue after injury. Here the authors study the effect of a growth factor, FGF2, on sea urchin regeneration but find no conclusive evidence for a pro-regenerative effect after spinal tissue injury.

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Algorithmic barriers: Investigating student perceptions of AI bias in subjective “culture fit” hiring

Mahatara et al. | May 25, 2026

Algorithmic barriers: Investigating student perceptions of AI bias in subjective “culture fit” hiring
Image credit: JonTyson

This study investigated perceptions of the emerging workforce toward the use of artificial intelligence in hiring, specifically for assessing subjective "culture fit." Through a mixed-methods survey of 150 high school and early-college students in Nepal, we found a significant disconnect between organizational adoption of AI and the profound skepticism of young job candidates, who express deep concerns about fairness, transparency, and the potential for AI to perpetuate systemic discrimination.

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Qualitative tracking of human and animation motions reveals differences in their walking gaits

Baily et al. | Oct 04, 2024

Qualitative tracking of human and animation motions reveals differences in their walking gaits

In their attempt to evoke a greater emotional connection with viewers, animators have strived to replicate human movements in their animations. However, animation movements still appear distinct from human movements. With a focus on walking, we hypothesized that animations, unaffected by real external forces (e.g. gravity), would move with a universally distinct, gliding gait that is discernible from humans.

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