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Polo-like kinase 1 (Plk1) is a master regulator of mitosis, initiating key steps of cell cycle regulation, and its overexpression is associated with certain types of cancer. In this study, the authors carefully designed peptides that were able to bind to Plk1 at a location that is important for its proper localization and function. Future studies could further develop these peptides to selectively target Plk1 in cancer cells and induce mitotic arrest.

α-amylase breaks down starch into glucose, which can cause blood sugar spikes and increase the risk of type II diabetes. This study tested natural extracts from cassia cinnamon and green tea as alternatives to synthetic inhibitors like acarbose, which can be costly and cause side effects.

This study analyzes genetic alterations and expression patterns of protein kinases involved in phagocytosis across multiple cancers using TCGA data.

The authors test the antiproliferative and apoptosis-inducing properties of an extract created from a traditional Indian medicinal plant of the Amaranthus genus.

The purpose of this study was to test the anti-cancer properties and pro-apoptotic effects of the polyherbal formulation MAT20 as a complementary treatment. Moringa oleifera (Moringa), Phyllanthus emblica (Amla) and Ocimum sanctum (Tulsi), these 3 herbs were used to formulate MAT20, which contain phytochemicals that are known to display anti-cancer properties. In this study, we hypothesized that MCF-7 breast cancer cells treated with MAT20 would show increased cytotoxicity compared to its individual plant extracts.

In this study, the authors develop a new hydrogel using photochemical crosslinking with bovine serum albumin and methylene blue. They find that this new hydrogel has some useful applications!

Luteolin (3′,4′,5,7-tetrahydroxyflavone) is a flavonoid that occurs in fruits, vegetables, and herbs. Research suggests that luteolin is effective against various forms of cancer by triggering apoptosis pathways. This experiment analyzes the effects of luteolin on the cell viability of malignant melanoma cells using an in vitro experiment to research alternative melanoma treatments and hopefully to help further cancer research as a whole.

Hydrogels are commonly used in medicine, pharmaceuticals, and agriculture. Hydrogels absorb water by swelling and re-release this water by diffusion. This study sought to synthesize a biodegradable, cellulose-based hydrogel that is more effective at absorbing and re-releasing water than those produced by current methods. We tested the compressive strength of both the dry and swollen gels and the tensile strength of the swollen gels to elucidate the gel structure.

Berberine is a natural quaternary alkaloid that has anti-microbial and anti-cancer effects. This compound can bind to Guanine Quadruplex (G4) DNA secondary complexes to help inhibit cancer cell proliferation. In this study, the authors investigate whether incorporating large aromatic rings helps to stabilize berberine-G4 interactions.

Studies show an age-related link between Alzheimer’s Disease and Type 2 Diabetes Mellitus with oxidative stress a characteristic of both. Here, methanolic fractionations and extracts of four Ayurvedic plants were assessed for their protective abilities using a number of in vitro assays. Extracts inhibited oxidative stress and reduced activity of key enzymes involved in the pathogenesis of both diseases in neuroblastoma cells.