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Here, through protein-ligand docking, the authors investigated the effect of the interaction of emodin with serine/threonine kinases, a subclass of kinases that is overexpressed in many cancers, which is implicated in phosphorylation cascades. Through molecular dynamics theyfound that emodin forms favorable interactions with chitosan and chitosan PEG (polyethylene glycol) copolymers, which could aid in loading drugs into nanoparticles (NPs) for targeted delivery to cancerous tissue. Both polymers demonstrated reasonable entrapment efficiencies, which encourages experimental exploration of emodin through targeted drug delivery vehicles and their anticancer activity.

Human cytomegalovirus (HCMV) causes serious infections in immunocompromised patients and therapies to inhibit latent HCMV are not developed. Using CRISPR/Cas9, the authors were able to delete an important promoter region in HCMV.

When granular materials are poured onto a surface, they form conical piles whose slopes increase before reaching a stable angle of repose. We found that this angle evolution follows a previously unrecognized two-phase exponential growth pattern that is conserved across granular materials with diverse particle properties. The parameters of this model correlate with particle friction and are influenced by deposition conditions, providing a quantitative framework for describing pile formation.

The authors looked at how different blends of synthetic and non-synthetic fabrics protected against UV radiation.

The authors looked at which measurements from the NFL combine were the most predictive of success for defensemen in the NFL.

The authors employ computational protein design to identify a mini-protein with the potential to enhance binding of the tight junction protein, claudin-5, at the blood-blood barrier with therapeutic potential for neurodegenerative diseases.

Investigation of the potential of waxworm saliva, the secretion of Galleria mellonella, for plastic degradation.

The authors looked at how students performed on standardized tests when they were taught material via memorization vs. conceptual based approaches.

The authors looked at four members of the tetracycline antibiotic family/class against four different species of bacteria.

Due to a critical shortage of donor hearts, researchers are exploring cardiac xenotransplantation—transplanting animal hearts into humans—as a potential solution. This study synthesized nearly two decades of preclinical research to evaluate multiple factors affecting xenograft survival.