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A five-year retrospective analysis of Tuberculosis risk factors and their variability in the United States

Kini et al. | Mar 14, 2026

A five-year retrospective analysis of Tuberculosis risk factors and their variability in the United States
Image credit: Kini, Diaz Gaviria, Diaz, and Kini

The main goal of this study is to determine what demographics are related to tuberculosis incidence in the United States populations, particularly if changing demographics are related to differences in tuberculosis risk over two discrete time periods. The major finding is that in the two studied time periods, tuberculosis risk factors were somewhat consistent and may be influenced by things such as immigration, healthcare access, and race or ethnicity, although the top predictor did change.

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Validating DTAPs with large language models: A novel approach to drug repurposing

Curtis et al. | Mar 02, 2025

Validating DTAPs with large language models: A novel approach to drug repurposing
Image credit: Growtika

Here, the authors investigated the integration of large language models (LLMs) with drug target affinity predictors (DTAPs) to improve drug repurposing, demonstrating a significant increase in prediction accuracy, particularly with GPT-4, for psychotropic drugs and the sigma-1 receptor. This novel approach offers to potentially accelerate and reduce the cost of drug discovery by efficiently identifying new therapeutic uses for existing drugs.

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