The authors looked at how acetaminophen may cause liver damage by looking at both serum level markers of liver damage as well as liver pathology.
Read More...Evaluation of hepatotoxicity from excessive acetaminophen: physiological and histological changes
The authors looked at how acetaminophen may cause liver damage by looking at both serum level markers of liver damage as well as liver pathology.
Read More...Investigating the potential of zinc oxide nanoparticles and zinc ions as promising approaches to lung cancer
Here, the authors chose to investigate the efficacy of zinc oxide nanoparticles (ZnO NPs) and cisplatin or zinc ions in inducing cancer apoptosis. While both treatments were found to reduce the proliferation of lung cancer cells, the authors suggest that further studies to identify the mechanism are necessary.
Read More...Design and in silico screening of analogs of rilpivirine as novel non-nucleoside reverse transcriptase inhibitors (NNRTIs) for antiretroviral therapy
In this study, the authors use high-throughput virtual screening to design and evaluate a set of non-nucleoside reverse transcriptase inhibitors for binding affinity to the protein reverse transcriptase. These studies have important applications toward HIV therapies.
Read More...The Potential of Fibroblast Growth Factors to Stimulate Hair Growth In Vitro
Identifying treatments that can stimulate hair growth use could help those struggling with undesirable hair loss. Here, the authors show that Fibroblast Growth Factors can stimulate the division of cells isolated from the mouse hair follicle. Their results suggest that this family of growth factors might be helpful in stimulating hair growth in living animals as well.
Read More...Immunogenicity of Minhai 13-valent pneumococcal polysaccharide conjugate vaccine in experimental mice
The authors looked at the immunogenicity of a newly developed pneumococcal conjugate vaccine compared to a previously developed one. They found the newly developed vaccine did elicit an immune response.
Read More...In silico screening of DEAB analogues as ALDH1 isoenzymes inhibitors in cancer treatment
The authors computationally screened potential ALDH1 inhibitors, for use as potential cancer therapeutics.
Read More...Mechanism and cytotoxicity of A1874 proteolysis targeting chimera on CT26 colon carcinoma cell line
This study investigates the effects of the PROTAC compound A1874 on CT26 colon carcinoma cells, focusing on its ability to degrade the protein BRD4 and reduce cell viability. While A1874 had previously shown effectiveness in other colon cancer cell lines, its impact on CT26 cells was unknown.
Read More...Identifying factors, such as low sleep quality, that predict suicidal thoughts using machine learning
Sadly, around 800,000 people die by suicide worldwide each year. Dong and Pearce analyze health survey data to identify associations between suicidal ideation and relevant variables, such as sleep quality, hopelessness, and anxious behavior.
Read More...Pediatric probiotic culture survival study in acidic pH using an in vitro model
In this study, the authors investigate the effects of acidity on the survival of commercial probiotic Lovebug bacterial strains.
Read More...Anticancer, anti-inflammatory, and apoptotic activities of MAT20, a poly-herbal formulation.
Kashyap Jha et al. look at the formulation of MAT20, a crude extract of the moringa, amla, and tulsi leaves, as a potential complementary and alternative medicine. Using HeLa cells, they find MAT20 up-regulates expression of inflammation and cell cytotoxicity markers. Their data is important for understanding the anti-cancer and anti-inflammatory properties of MAT20.
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