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Quantifying right atrial dilation relative to atrial septal defect size using an experimental model

Lee et al. | Dec 06, 2025

Quantifying right atrial dilation relative to atrial septal defect size using an experimental model
Image credit: jesse orrico

To address the limitations in predicting the severity of Atrial Septal Defect (ASD), here the authors utilized a fluid-filled chamber model to quantify the relationship between defect size and right atrial fluid output. The findings confirmed that larger ASD diameters result in a linear increase in fluid output, validating a cost-effective model that can improve clinical prognosis and treatment planning for heart failure risks.

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Relationship between p62 and learning behavior in male and female mice deficient in hippocampal folliculin

Guvenir et al. | Jun 10, 2025

Relationship between p62 and learning behavior in male and female mice deficient in hippocampal folliculin
Image credit: Robina Weermeijer

Here the authors hypothesized that reducing folliculin (FLCN) might affect p62 protein levels in the dorsal hippocampus of mice, given their potential functional connection and p62's role in neurodegenerative diseases. Their study, using western blots and a two-way ANOVA on young wild-type mice, found that p62 levels correlated with FLCN expression, but ultimately concluded there's no evidence of a functional connection between FLCN and p62 in this specific model.

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A HOG feature extraction and CNN approach to Parkinson’s spiral drawing diagnosis

Tripathi et al. | Aug 09, 2024

A HOG feature extraction and CNN approach to Parkinson’s spiral drawing diagnosis

Parkinson’s disease (PD) is a prevalent neurodegenerative disorder in the U.S., second only to Alzheimer’s disease. Current diagnostic methods are often inefficient and dependent on clinical exams. This study explored using machine and deep learning to enhance PD diagnosis by analyzing spiral drawings affected by hand tremors, a common PD symptom.

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Study of PINN sensor layout in evaluating WSS with application to patient-specific carotid flow

Nie et al. | Sep 04, 2026

Study of PINN sensor layout in evaluating WSS with application to patient-specific carotid flow

Physics‑Informed Neural Networks (PINNs) offer a promising way to estimate blood‑flow behavior in arteries, especially near the vessel wall where traditional methods struggle. In this study, students tested how sensor density and placement affect PINN accuracy in modeling carotid artery flow and found that accuracy improves up to a moderate sensor density and depends strongly on how close sensors are placed to the arterial wall. Applying the optimized configuration to a patient‑specific carotid model produced velocity predictions closely matching computational fluid dynamics results, highlighting PINNs’ potential for future personalized cardiovascular assessment.

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Global trends in total cholesterol by gender (1980-2018)

Qi et al. | Aug 24, 2026

Global trends in total cholesterol by gender (1980-2018)

This study explores global trends in average total cholesterol levels among adults from 1980 to 2018, finding a significant decline in both men and women, with a sharper decrease among men. While these improvements likely reflect advances in public health and medical treatment, the persistent gender gap highlights the need for more targeted approaches to cardiovascular disease prevention.

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