The authors looked at whether traditional Chinese medicine remedies that target the lungs and liver would reduce inflammation in a planaria model. They found that the two active compounds they tested were able to decrease induced inflammation by 97-98%.
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Investigation of the impact of acid reflux on dental cements
The authors test the effects of pH level on different kinds of dental cement to model the long-term effects of reflux-induced stomach acid exposure.
Read More...Quantifying right atrial dilation relative to atrial septal defect size using an experimental model
To address the limitations in predicting the severity of Atrial Septal Defect (ASD), here the authors utilized a fluid-filled chamber model to quantify the relationship between defect size and right atrial fluid output. The findings confirmed that larger ASD diameters result in a linear increase in fluid output, validating a cost-effective model that can improve clinical prognosis and treatment planning for heart failure risks.
Read More...Relationship between p62 and learning behavior in male and female mice deficient in hippocampal folliculin
Here the authors hypothesized that reducing folliculin (FLCN) might affect p62 protein levels in the dorsal hippocampus of mice, given their potential functional connection and p62's role in neurodegenerative diseases. Their study, using western blots and a two-way ANOVA on young wild-type mice, found that p62 levels correlated with FLCN expression, but ultimately concluded there's no evidence of a functional connection between FLCN and p62 in this specific model.
Read More...A HOG feature extraction and CNN approach to Parkinson’s spiral drawing diagnosis
Parkinson’s disease (PD) is a prevalent neurodegenerative disorder in the U.S., second only to Alzheimer’s disease. Current diagnostic methods are often inefficient and dependent on clinical exams. This study explored using machine and deep learning to enhance PD diagnosis by analyzing spiral drawings affected by hand tremors, a common PD symptom.
Read More...De novo design of a dual-target inhibitor against tau phosphorylation and acetylation for Alzheimer's therapy
The authors use computational methods to compare tau acetylation to the better studied tau phosphorylation in Alzheimer's disease and then design and computationally test a new drug to prevent abnormal post-translational modifications of tau.
Read More...Study of PINN sensor layout in evaluating WSS with application to patient-specific carotid flow
Physics‑Informed Neural Networks (PINNs) offer a promising way to estimate blood‑flow behavior in arteries, especially near the vessel wall where traditional methods struggle. In this study, students tested how sensor density and placement affect PINN accuracy in modeling carotid artery flow and found that accuracy improves up to a moderate sensor density and depends strongly on how close sensors are placed to the arterial wall. Applying the optimized configuration to a patient‑specific carotid model produced velocity predictions closely matching computational fluid dynamics results, highlighting PINNs’ potential for future personalized cardiovascular assessment.
Read More...Environmental contributors of asthma via explainable AI: Green spaces, climate, traffic & air quality
This study explored how green spaces, climate, traffic, and air quality (GCTA) collectively influence asthma-related emergency department visits in the U.S using machine learning models and explainable AI.
Read More...Global trends in total cholesterol by gender (1980-2018)
This study explores global trends in average total cholesterol levels among adults from 1980 to 2018, finding a significant decline in both men and women, with a sharper decrease among men. While these improvements likely reflect advances in public health and medical treatment, the persistent gender gap highlights the need for more targeted approaches to cardiovascular disease prevention.
Read More...Towards multimodal longitudinal analysis for predicting cognitive decline
Understanding and predicting cognitive decline in Alzheimer's disease
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