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In this study, the authors looked at a proto-oncogene, KRAS, and searched for molecules that are predicted to be able to bind to the inactive form of KRAS. They found that a modified version of Irbesartan, a derivative of benzimidazole, showed the best binding to inactive KRAS.

Someday, rockets from Earth may be launched towards worlds beyond our solar system. But will these rockets be able to reach their destination within a human lifetime? Ramaswamy and Giovinazzi simulate rocket launches to an Earth-like exoplanet to uncover whether it's physically possible to complete the journey within a lifetime.

The authors develop and test a machine learning algorithm for predicting diabetes diagnoses.

Social media is widely used and easily accessible for adolescents, it has the potential to increase STEM (Science, Technology, Engineering, and Math) identity in girls. We aimed to investigate the effects of exposure to counter-stereotypical portrayals of women in STEM on social media on the STEM identity of adolescent girls. The study concluded that social media alone may not be an effective tool to increase STEM identity in girls. Social media can still be used as a complementary tool to support and encourage women in STEM, but it should not be relied upon solely to address the gender disparity in STEM fields.

The authors propose a method to help first responders find the location of a person within a high-rise building in densely populated areas.

Natural selection shapes the evolution of all organisms, and one question of interest is whether natural selection will reach a "stopping point": a stable, ideal, value for any particular trait. Madhan and Kanagavel tackle this question by building a computer simulation of trait evolution in organisms.

The authors identify disinfectant-resistant bacterial strains of infection-causing bacteria from samples collected at a hospital setting.

Major depressive disorder (MDD) is a prevalent mood disorder. The direct causes and biological mechanisms of depression still elude understanding, though genetic factors have been implicated. This study looked to identify the mechanism behind the aberrant response to the dexamethasone suppression test (DST) displayed by MDD patients, in which they display a lack of cortisol suppression. Analysis revealed several pro-inflammatory genes that were significant and differentially expressed between affected and non-affected groups in response to the DST. Looking at ways to decrease the inflammatory response could have implications for treatment and may explain why some people treated for depression still display symptoms or may lead researchers to different classes of drugs for treatment.

Recent research suggests that the "American Dream" of income mobility may be becoming increasingly hard to obtain. Datta and Schmitz explore the role of government spending in socioeconomic opportunity by determining which state government spending components are associated with increased income mobility.

Spinal degeneration has been linked to critical conditions such as osteoarthritis in adults aged 40+; while this condition is considered to be irreversible, we took interest in magnetic resonance imaging (MRI) for early detection of the condition. Ultimately, our purpose was to determine the effectiveness of a relatively novel T1rho method in the early detection of spinal degeneration, and we hypothesized that the early to mild progression of spinal degeneration would affect T1rho values following an MRI scan.