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Leaky expression of PRMT1 in Escherichia coli and redox regulation of its histone methyltransferase activity

Kim et al. | Oct 07, 2026

Leaky expression of PRMT1 in <i>Escherichia coli</i> and redox regulation of its histone methyltransferase activity

This study characterizes recombinant human Protein arginine methyltransferase 1 (PRMT1) expressed in Escherichia. coli and reveals that the enzyme exhibits leaky expression even without isopropyl β-D-1-thiogalactopyranoside (IPTG) induction. Through in vitro histone methyltransferase assays, we demonstrate that PRMT1 activity toward histone H4R3 is enhanced by dithiothreitol (DTT) in a dose-dependent manner but remains unresponsive to β-mercaptoethanol. These findings highlight the critical role of redox conditions in regulating PRMT1 catalytic function and provide a practical framework for future biochemical and kinetic studies.

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Optimizing website performance: A comprehensive Google Lighthouse study on desktop and mobile modes

S. Al-Majidi et al. | Oct 02, 2026

Optimizing website performance: A comprehensive Google Lighthouse study on desktop and mobile modes

In this study, we examined the consistency and dependability of Google's Lighthouse tool for measuring website performance, accessibility, SEO, and best practices. Tests conducted on three websites showed that performance scores vary based on the testing mode and website complexity, while other audit categories stay constant. These results provide direction for researchers and developers by highlighting Lighthouse's benefits and drawbacks.

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Multi-omic analysis identifies mitochondrial dysfunction as a key feature of hypertrophic cardiomyopathy

Velu et al. | Sep 26, 2026

Multi-omic analysis identifies mitochondrial dysfunction as a key feature of hypertrophic cardiomyopathy

This study used multi-omic analysis to investigate gene expression and DNA methylation patterns associated with hypertrophic cardiomyopathy (HCM). The researchers found significant downregulation of mitochondrial and energy-related pathways, highlighting mitochondrial dysfunction—particularly altered PINK1 expression—as a potential contributor and therapeutic target in HCM.

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Comparison of shower filters for reducing total residual chlorine under household flow conditions

Lee et al. | Sep 19, 2026

Comparison of shower filters for reducing total residual chlorine under household flow conditions
Image credit: Micheile Henderson

This study compared two commercial shower filters and three individual filtration media to evaluate their ability to reduce total residual chlorine under household flow conditions. By identifying which materials most effectively reduce chlorine during regular shower use, this research provides practical information for consumers and offers guidance for designing more affordable and reusable shower filtration systems.

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