COVID-19 has impacted the way many people go about their daily lives, but what are the main factors driving the changes in the housing market, particular house prices?
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Testing HCN1 channel dysregulation in the prefrontal cortex using a novel piezoelectric silk neuromodulator
Although no comprehensive characterization of schizophrenia exists, there is a general consensus that patients have electrical dysfunction in the prefrontal cortex. The authors designed a novel piezoelectric silk-based implant and optimized electrical output through the addition of conductive materials zinc oxide (ZnO) and aluminum nitride (AlN). With further research and compatibility studies, this implant could rectify electrical misfiring in the infralimbic prefrontal cortex.
Read More...Predicting Orbital Resonance of 2867 Šteins Using the Yarkovsky Effect
In this study, the impact of thermal effects on the orbit of an asteroid is investigated. This included determining if the asteroid's orbit would push into a region devoid of asteroids due to the gravitational pull of Jupiter.
Read More...Regenerative Effects of Turmeric and Alpha-Lipoic Acid in Lumbriculus variegatus
This study examines the effects of tumeric, and alph-lipoic acid on segment regeneration and cardiovascular pulse rate, using the California blackworm. Results can ultimately demonstrate potential natural compounds for tissue repair and their effect on physiological activity.
Read More...COVID-19 and air pollution in New York City
Did the COVID-19 pandemic and travel restrictions improve air quality? The authors investigate this question in New York City using existing pollution data and forecasting trends.
Read More...A comparative analysis of machine learning approaches to predict brain tumors using MRI
The authors use machine learning on MRI images of brain tissue to predict tumor onset as an avenue for early detection of brain cancer.
Read More...Deuterated solvent effects in the kinetics and thermodynamics of keto-enol tautomerization of ETFAA
In this study, the authors determined whether tautomerization dynamics in protic and aprotic solvents displayed differences in reaction rates and in the proportion of the keto and enol tautomers present.
Read More...India’s digital public infrastructure: Analyzing UPI and Aadhaar in GDP growth and cost optimization
India’s Digital Public Infrastructure (DPI)—including the Unified Payments Interface (UPI) and Aadhaar—has been globally recognized for advancing financial inclusion and efficient governance. This study analyzes data from 2016–17 to 2023–24 the impact of these services on India's GDP.
Read More...The design of Benzimidazole derivatives to bind to GDP-bound K-RAS for targeted cancer therapy
In this study, the authors looked at a proto-oncogene, KRAS, and searched for molecules that are predicted to be able to bind to the inactive form of KRAS. They found that a modified version of Irbesartan, a derivative of benzimidazole, showed the best binding to inactive KRAS.
Read More...Using explainable artificial intelligence to identify patient-specific breast cancer subtypes
Breast cancer is the most common cancer in women, with approximately 300,000 diagnosed with breast cancer in 2023. It ranks second in cancer-related deaths for women, after lung cancer with nearly 50,000 deaths. Scientists have identified important genetic mutations in genes like BRCA1 and BRCA2 that lead to the development of breast cancer, but previous studies were limited as they focused on specific populations. To overcome limitations, diverse populations and powerful statistical methods like genome-wide association studies and whole-genome sequencing are needed. Explainable artificial intelligence (XAI) can be used in oncology and breast cancer research to overcome these limitations of specificity as it can analyze datasets of diagnosed patients by providing interpretable explanations for identified patterns and predictions. This project aims to achieve technological and medicinal goals by using advanced algorithms to identify breast cancer subtypes for faster diagnoses. Multiple methods were utilized to develop an efficient algorithm. We hypothesized that an XAI approach would be best as it can assign scores to genes, specifically with a 90% success rate. To test that, we ran multiple trials utilizing XAI methods through the identification of class-specific and patient-specific key genes. We found that the study demonstrated a pipeline that combines multiple XAI techniques to identify potential biomarker genes for breast cancer with a 95% success rate.
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