The authors looked at how acetaminophen may cause liver damage by looking at both serum level markers of liver damage as well as liver pathology.
Read More...Evaluation of hepatotoxicity from excessive acetaminophen: physiological and histological changes
The authors looked at how acetaminophen may cause liver damage by looking at both serum level markers of liver damage as well as liver pathology.
Read More...The non-nutritive sweeteners acesulfame potassium and neotame slow the regeneration rate of planaria
The consumption of sugar substitute non-nutritive sweeteners (NNS) has dramatically increased in recent years. Despite being advertised as a healthy alternative, NNS have been linked to adverse effects on the body, such as neurodegenerative diseases (NDs). In NDs, neural stem cell function is impaired, which inhibits neuron regeneration. The purpose of this study was to determine if the NNS acesulfame potassium (Ace-K) and neotame affect planaria neuron regeneration rates. Since human neurons may regenerate, planaria, organisms with extensive regenerative capabilities due to stem cells called neoblasts, were used as the model organism. The heads of planaria exposed to either a control or non-toxic concentrations of NNS were amputated. The posterior regions of the planaria were observed every 24 hours to see the following regeneration stages: (1) wound healing, (2) blastema development, (3) growth, and (4) differentiation. The authors hypothesized that exposure to the NNS would slow planaria regeneration rates. The time it took for the planaria in the Ace-K group and the neotame group to reach the second, third, and fourth regeneration stage was significantly greater than that of the control. The results of this study indicated that exposure to the NNS significantly slowed regeneration rates in planaria. This suggests that the NNS may adversely impact neoblast proliferation rates in planaria, implying that it could impair neural stem cell proliferation in humans, which plays a role in NDs. This study may provide insight into the connection between NNS, human neuron regeneration, and NDs.
Read More...Effect of pH on the antibacterial properties of turmeric
Some spices have antimicrobial or antibacterial properties that people have already tested. Turmeric has a wide variety of uses and has even been implemented in alternative medicine as a treatment for cancer, inflammation, osteoarthritis, and other diseases. We tested the antimicrobial effects of turmeric under two different pHs to characterize this effect in vitro. Decreasing the pH of a solution of turmeric may increase antibacterial properties.
Read More...Environmental contributors of asthma via explainable AI: Green spaces, climate, traffic & air quality
This study explored how green spaces, climate, traffic, and air quality (GCTA) collectively influence asthma-related emergency department visits in the U.S using machine learning models and explainable AI.
Read More...Upward social comparison on standardized test performance in adolescents and adults
The authors test the effect of test score comparison on the self-efficacy of adolescents versus adults.
Read More...The effect of adverse childhood experiences on e-cigarette usage in people aged 18–30 in the US
Recently, e-cigarette usage has been increasing rapidly. Previous research has found that adverse
childhood experiences (ACEs) are correlated to cigarette usage. However, there is limited data exploring if ACEs affect vaping. Therefore, in this work, we investigated the effects of ACEs on e-cigarette usage and hypothesize that witnessing vaping in the house and facing ACEs would increase e-cigarette usage while education on the dangers of vaping would decrease e-cigarette usage. We found that different types of ACEs had different correlations with e-cigarette usage and that education on the dangers of vaping had no effect on e-cigarette usage.
Chlorpyrifos exposure in mice leads to altered expression of key neurodevelopmental proteins
Impacts of childhood adversity on relationships: Expressions of affection and social connection
The authors survey adults to assess how childhood adversity may impact adult relationships and ways of giving or receiving affection.
Read More...Investigating the impact of short-chain fatty acids on myofiber dynamics and insulin sensitivity
The authors looked at the impacts of short-chain fatty acids on muscle fiber formation as well as insulin sensitivity using a model of mouse myoblasts.
Read More...Enhanced Iron and Manganese Removal Using Nanocomposite CA/PVP Membranes Doped with CNC, CNF, and HNT
We developed new eco-friendly membranes enriched with natural nanomaterials to clean iron and manganese from drinking water. Some nanocomposite membranes achieved over 95% metal removal while maintaining water flux, suggesting improved performance compared to the undoped control group.
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