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Impact of gadodiamide (Omniscan) on a beef liver catalase ex vivo model

Hirsch et al. | Mar 10, 2023

Impact of gadodiamide (Omniscan) on a beef liver catalase <em>ex vivo</em> model
Image credit: Marcelo Leal

Here, seeking to better understand the effects of gadolinium-based contrast agents, dyes typically used for MRI scans, the authors evaluated the activity of catalase found in beef liver both with and without gadodiamide when exposed to hydrogen peroxide. They found that gadioamide did not significantly inhibit catalase's activity, attributing this lack of effects to the chelating agent found in gadodiamide.

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Transfer Learning for Small and Different Datasets: Fine-Tuning A Pre-Trained Model Affects Performance

Gupta et al. | Oct 18, 2020

Transfer Learning for Small and Different Datasets: Fine-Tuning A Pre-Trained Model Affects Performance

In this study, the authors seek to improve a machine learning algorithm used for image classification: identifying male and female images. In addition to fine-tuning the classification model, they investigate how accuracy is affected by their changes (an important task when developing and updating algorithms). To determine accuracy, a set of images is used to train the model and then a separate set of images is used for validation. They found that the validation accuracy was close to the training accuracy. This study contributes to the expanding areas of machine learning and its applications to image identification.

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The Effects of Ezetimibe on Triglyceride and Alanine Transaminase Reduction in Drosophila Melanogaster Model of Nonalcoholic Fatty Liver Disease (NAFLD)

Dania et al. | Apr 30, 2020

The Effects of Ezetimibe on Triglyceride and Alanine Transaminase Reduction in <i>Drosophila Melanogaster</i> Model of Nonalcoholic Fatty Liver Disease (NAFLD)

Nonalcoholic Fatty Liver Disease (NAFLD) is a condition where a surplus of triglycerides or fat are present in the liver. In this study, ezetimibe, a cholesterol lowering drug, was used to treat flies modeling NAFLD. Compared to the coconut oil fed flies that were transferred to the control medium, the flies transferred to the control medium treated with ezetimibe showed a decrease in their triglyceride and alanine transaminase level.

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Temperature and Precipitation Responses to a Stratospheric Aerosol Geoengineering Experiment Using the Community Climate System Model 4

Anderson et al. | Aug 19, 2014

Temperature and Precipitation Responses to a Stratospheric Aerosol Geoengineering Experiment Using the Community Climate System Model 4

We are changing our environment with steadily increasing carbon dioxide emissions, but we might be able to help. The authors here use a computer program called Community Climate System Model 4 to predict the effects of spraying small particles into the atmosphere to reflect away some of the sun's rays. The software predicts that this could reduce the amount of energy the Earth's atmosphere absorbs and may limit but will not completely counteract our carbon dioxide production.

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Characterizing the association between hippocampal reactive astrogliosis, anhedonia-like behaviors, and neurogenesis in a monkey model of stress and antidepressant treatment

Kim et al. | Aug 25, 2022

Characterizing the association between hippocampal reactive astrogliosis, anhedonia-like behaviors, and neurogenesis in a monkey model of stress and antidepressant treatment

This study examined the effects of stress and selective serotonin reuptake inhibitors (SSRIs) on a measure of astrocyte reactivity in nonhuman primate (NHP) models of stress. Results showed that chronic separation stress in NHPs leads to increased signs of astrogliosis in the NHP hippocampus. The findings were consistent with the hypotheses that hippocampal astrogliosis is an important mechanism in stress-induced cognitive and behavioral deficits.

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